In present work, new method of fabricating metal phosphates via interaction of metal oleates with tributylphosphate solution is presented. Developed method is the universal one for fabrication of nanosized powders and thinlayered coatings based on hydroxyapatite, which is doped with metal traces (Sr, Cu, Zn) and presenting essential basis of bone tissue. Method provides formation of composites (powders/coatings) of predetermined dispersity 50±20 nm and porosity (pore size ranged 20-100 nm), determined by synthesis conditions.Besides, method of bioglass fabrication of various composition from organic solutions, containing Ca, Si, Na and P, is suggested. One of the advantages of this method is that such precursor solutions during modification of bioinert support easily penetrate into any pores and after annealing form thin films, which totally reproduce surface texture that cannot be achieved using batch mixtures or sols. Uniqueness of suggested method is possibility to create glass ceramics coatings of multilayer type on various bioinert supports without alteration (degradation) of developed surface microrelief. In addition to that, method allows controlling the thickness of applied layers of biocoating preserving complex microgeometry of support surface, in particular, coating samples were obtained on supports with hierarchical (biporous) structure: pores sized 0.5-2 µm and 10-20 µm with roughness ranged from 1 to 10 µm.Method of plasma-electrolytic oxidation (PEO) of titanium products with consequent application on their surface tantalum-containing extract and formation of multilayer coatings with developed microrelief and predetermined thickness of 15±2 µm, on the surface of which regions enriched with tantalum oxide, titanium oxide and calcium phosphates alternate. Coatings of this type can show unique bifunctional properties that are inherent both in tantalum oxides and in calcium phosphates. It has been shown, that using PEO method for modification of titanium in electrolytes with Ca(II) and Sr(II) complexes the formation of oxide-phosphate coatings of calcium and strontium is provided and ratios of elements are accurately controlled by concentrations of respective polyphosphate anions in electrolyte. This approach is prospective for application on titanium implants coatings, containing calcium phosphates with additives of other metal phosphates, and also for creating on implants of electret coatings.Regeneration of bone tissue after implanting calcium-phosphate materials, namely nanosized powders of original and strontium-substituted hydroxyapatite, is investigated in vivo. Obtained bone implants favor bone morphogenesis, which progresses fully, at more intense pace, with minimal reactive changes in certain regions of the tissue.

Ссылка на оригинал статьи